LDL modified by smooth muscle cells in the presence of L-cystine and Cu(II) was taken up and degraded less well than native LDL by human skin fibroblasts, suggesting that recognition by the LDL receptor was lost. LDL modification also required micromolar concentrations of the transition metal ion Cu(II) or Fe(III) and was inhibited by superoxide dismutase. Modification of low density lipoprotein (LDL) by arterial smooth muscle cells, as assessed by changes in lipid peroxide content, mobility on agarose gel electrophoresis, and apoprotein B fragmentation, was also L-cystine-dependent. This effect was maximal when the chelator was present at the same concentration as the sum of the Ca2+ and Mg2+ in the medium, suggesting a role for these cations in O2. At millimolar concentrations, the chelators EDTA and diethylene triamine penta-acetic acid inhibited O2. generation when present at concentrations equimolar to L-cystine. A variety of other sulfur-containing amino acids, including D-cystine, L-cystathionine, L-methionine, and djenkolic acid did not support O2. Reduction of cytochrome c by these cells required L-cystine in the incubation medium. Version: 1.12 Updated: Size: 6.6 MB License: Proprietary Works with: Media Monkey 4.0 - 4.Extracellular superoxide (O2-.) was detected in cultures of monkey arterial smooth muscle cells as measured by the superoxide dismutase-inhibitable reduction of cytochrome c and acetylated cytochrome c. Version: 2.0.1.15 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Changes:įixed 9124: Converting some specific MP4/H264 files to MP4/H264 gives corrupted image Version: 2.0.0.14 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Changes: Fixed 8084: AV in f_aac_codec.dll on attempt to change rating or tag of an ALAC file during playback.įixed 8147: Codec Pack: 96 kHz/16 bit ALAC plays back 1/2 speed. Version: 2.2.0.106 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Changes:įixed cannot play certain ALAC files Version: 2.1.2.105 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Version: 2.1.1.103 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Version: 2.0.2.17 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Changes:Īdds a workaround for compatibility when MediaMonkey is run in portable mode. Version: 2.3.0.107 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Changes:įixed crash with malformated alac files. Version History / Details Version: 2.3.0.108 Updated: License: Proprietary Works with: Media Monkey 4.0 - 4.9 Changes:įixed crash with malformatted alac files.

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